- Samuel Codes Watson, medical student, is the first known African American student admitted to the university.
- William V. Snyder awarded the first Engineering degree.
- Alice Boise Wood is the first woman to attend classes (in Greek) as an unregistered student at U-M.
- Madelon Louisa Stockwell, is the first woman admitted to the university. She was also the first graduate to marry a classmate in 1872.
- Amanda Sanford becomes first alumna of U-M by graduating from the medical school
- Sarah Killgore of Crawfordsville, Indiana, graduated with a law degree on the same day.
- Saiske Tagai is the first Asian student (Japanese) admitted to the University of Michigan.
- Mary Henrietta Graham, lit. 1880, is the first known African American woman admitted to the university.
- José Celso Barbosa becomes the first Puerto Rican student to enroll at U-M, and is an alumnus of the Department of Medicine and Surgery ’80.
- Grace Roberts becomes the first African American to earn a MD (Homeopathy).
- June Rose Colby is the first woman to receive a Ph.D. upon examination (She received graduate degrees in 1885 and 1886).
- Fred B. Pelham becomes the first African-American to earn Civil Engineering degree.
- Ida Gray becomes the first African American woman to graduate in dentistry.
- The First Chinese students, Mary Stone and Ida Kahn, are admitted to U-M.
- Marian Sarah Parker becomes the first woman to graduate with a B.S.E. in Civil Engineering.
- Suzan Rose Benedict is the first woman to receive a Ph.D. in mathematics at U-M.
- Elmer Samuel Imes becomes the first African American to earn a Ph.D. in physics.
- Willie Hobbs Moore is the first African American woman to earn a degree in engineering.
- The first undergraduate male nursing students graduate. The first male completed the nursing graduate program in 1964.
- Willie Hobbs Moore becomes the first African American woman to receive a Ph.D. in physics.